Probability of Identity by Descent in Metapopulations

Probability of identity by descent in metapopulations.

Equilibrium probabilities of identity by descent (IBD), for pairs of genes within individuals, for genes between individuals within subpopulations, and for genes between subpopulations are calculated in metapopulation models with fixed or varying colony sizes. A continuous-time analog to the Moran model was used in either case. For fixed-colony size both propagule and migrant pool models were c...

Probability of gene identity by descent: computation and applications.

Two genes at a given locus are identical by descent (IBD) if both have been inherited from a common ancestor. We present an algorithm for computing the probabilities of all IBD relationships among the genes of pedigree members. We show how to use these probabilities to calculate the probability of any combination of genotypes or phenotypes for the pedigree members. Applications to linkage analy...

A Revised Li-Sacks Formula For Calculating the Probability of Identity-by-Descent Proportion

Prediction of multilocus identity-by-descent.

Previous studies have enabled exact prediction of probabilities of identity-by-descent (IBD) in random-mating populations for a few loci (up to four or so), with extension to more using approximate regression methods. Here we present a precise predictor of multiple-locus IBD using simple formulas based on exact results for two loci. In particular, the probability of non-IBD X(ABC) at each of or...

Population Genetics of Identity By Descent

Population Genetics of Identity By Descent Pier Francesco Palamara Recent improvements in high-throughput genotyping and sequencing technologies have afforded the collection of massive, genome-wide datasets of DNA information from hundreds of thousands of individuals. These datasets, in turn, provide unprecedented opportunities to reconstruct the history of human populations and detect genotype...